KMID : 1036920190240020133
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Annals of Pediatric Endocrinology & Metabolism 2019 Volume.24 No. 2 p.133 ~ p.136
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Thyrotoxic hypokalemic periodic paralysis due to Graves¡¯ disease in 2 adolescents
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Roh Jung-Gi
Park Kyu-Jung Lee Hae-Sang Hwang Jin-Soon
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Abstract
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Thyrotoxic periodic paralysis (TPP) is a notable and potentially lethal complication of thyrotoxicosis, and Graves¡¯ disease is the most common cause of TPP. TPP is commonly reported in Asian males between 20?40 years of age, but it is rare in children and adolescents. We report 2 Korean adolescents (a 16-year-old male and a 14-year-old female) with episodes of TPP who were previously diagnosed with Graves¡¯ disease. These 2 patients presented with lower leg weakness in the morning after waking up. They were diagnosed with TPP-associated with thyrotoxicosis due to Graves¡¯ disease. After they were initially treated with potassium chloride and antithyroid drugs, muscle paralysis improved and an euthyroid state without muscle paralytic events was maintained during follow-up. Therefore, clinicians should consider TPP when patients have sudden paralysis and thyrotoxic symptoms such as goiter, tachycardia, and hypertension.
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KEYWORD
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Thyrotoxic periodic paralysis, Hypokalemia, Graves¡¯ disease
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